The Mona Lisa plays a significant role in discussions about the commodification of art as it is often used as a prime example of how iconic artworks can become heavily commodified. The painting's fame and value have led to various commercial activities such as merchandise, reproductions, and licensing agreements, highlighting the intersection of art, consumerism, and capitalism. This has sparked debates about the commercialization of art and the impact it has on the integrity and authenticity of artistic works.