The Mona Lisa holds significance in discussions about the globalization of art and culture as it is a universally recognized symbol of art that has transcended national borders and become a global icon. Its fame and appeal have contributed to the globalization of art by serving as a point of reference in conversations about artistic influence, cultural exchange, and the interconnectedness of societies worldwide. The painting's widespread recognition has also sparked debates about cultural ownership, authenticity, and the commodification of art in the global market.