Domesticated rabbits have been bred over generations for specific traits such as size, coat color, and temperament, while wild rabbits have evolved to survive in their natural habitats. Domesticated rabbits are typically larger in size and have a wider variety of coat colors compared to wild rabbits. In terms of behavior, domesticated rabbits are usually more docile and tolerant of human interaction, whereas wild rabbits are more cautious and skittish around humans. Additionally, domesticated rabbits rely on humans for food and shelter, while wild rabbits forage for food and create burrows for shelter in the wild.