Domesticated rabbits are bred to be more docile and friendly towards humans, while wild rabbits are typically more skittish and fearful of humans. Domesticated rabbits may have a wider variety of coat colors and patterns compared to wild rabbits. In terms of behavior, wild rabbits are more adept at surviving in the wild, while domesticated rabbits rely on humans for food and shelter. Additionally, domesticated rabbits may have a more predictable diet compared to wild rabbits, who forage for food in their natural habitats.