One key difference between Bitcoin and Ethereum is their primary purpose and functionality. Bitcoin was created as a digital currency and is primarily used for peer-to-peer transactions and store of value. On the other hand, Ethereum is a decentralized platform that enables smart contracts and decentralized applications (DApps) to be built on its blockchain. Another significant difference is their consensus mechanisms. Bitcoin uses the proof-of-work (PoW) consensus algorithm, while Ethereum is transitioning from PoW to proof-of-stake (PoS). Additionally, Ethereum has a much more complex scripting language which allows developers to create a wider range of applications compared to Bitcoin's more limited scripting capabilities.