Some signs of respiratory issues in rats include:
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Labored breathing or wheezing
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Sneezing or coughing
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Nasal discharge or congestion
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Reduced activity or lethargy
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Loss of appetite
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Unusual sounds while breathing, like clicking noises
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Weight loss
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Puffed-up fur or hunched posture
If you notice any of these signs in your rat, it's important to consult a veterinarian who is experienced in treating small animals like rats.