Yes, lack of sleep can affect skin appearance. When you don't get enough sleep, your body produces more of the stress hormone cortisol, which can break down collagen in the skin. This can lead to an increase in fine lines, wrinkles, and dullness of the skin. Additionally, lack of sleep can also cause under-eye circles, puffiness, and a general lackluster appearance in the skin. It's important to prioritize getting enough sleep for overall skin health and appearance.