The key interactions between Karasuno and Shiratorizawa in the anime "Haikyuu!!" mainly revolve around their intense volleyball matches during the Spring High Nationals tournament. Their interactions include fierce rallies, strategic plays, strong spikes, and intense blocks that showcase the competitive spirit and determination of both teams. Additionally, the interactions also involve personal rivalries between individual players, coaching strategies, and the mutual respect that develops between the teams as they push each other to improve and give their best on the court.