Karasuno exploits their opponents' weaknesses during matches by closely studying their playing style, strategies, and individual players beforehand. They pay attention to patterns, tendencies, and potential weaknesses that can be targeted. During matches, Karasuno's players communicate effectively with each other to adjust their tactics accordingly and capitalize on the identified weaknesses. Additionally, their coach, Ukai, provides insightful advice and guidance to help the team make strategic decisions in real-time based on the opponent's vulnerabilities.