Seishiro Nagi's relationship with Reo Mikage undergoes a significant transformation throughout the series. Initially, they start off as rivals with conflicting goals and ideologies. However, as the series progresses, they begin to understand each other better and develop a mutual respect for one another. Their relationship evolves from animosity to a complex mixture of friendship, trust, and collaboration as they face common challenges and obstacles together. Ultimately, they become close allies who rely on each other for support and guidance in their shared journey.