Yes, it is generally safe to keep pet spiders as long as proper precautions are taken. It is important to research the specific species of spider you are interested in keeping to understand their care requirements and potential risks. Some spiders have venom that can be harmful to humans, so it is important to handle them carefully and avoid getting bitten. Overall, if you are knowledgeable about spiders and take appropriate safety measures, keeping them as pets can be a rewarding experience.