Signs of a sick guinea pig can include:
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Loss of appetite
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Weight loss
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Lethargy
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Hiding more than usual
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Rough or puffed-up fur
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Labored breathing
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Sneezing or coughing
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Watery eyes or nose
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Diarrhea or constipation
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Changes in behavior or vocalizations
If you notice any of these signs in your guinea pig, it's important to consult a veterinarian experienced with guinea pigs for proper diagnosis and treatment.