Food additives and preservatives can impact human health in the long term in several ways. Some studies suggest that certain food additives and preservatives may be linked to health issues such as allergies, digestive problems, and potential carcinogenic effects. Additionally, consuming foods high in additives and preservatives may contribute to an increased risk of chronic diseases such as obesity, diabetes, and cardiovascular disease over time. It is important to read food labels carefully and consume a balanced diet rich in whole foods to minimize the potential long-term impact of food additives and preservatives on health.