The best way to groom a cat is to start by brushing their fur regularly to remove loose hair and prevent matting. Use a brush or comb specifically designed for cats, and be gentle to avoid causing discomfort. Additionally, you can trim your cat's nails, clean their ears, and brush their teeth to maintain their overall hygiene. It's also important to monitor your cat's skin and coat for any signs of health issues. If your cat is uncomfortable with grooming, you may want to consider taking them to a professional groomer for assistance.