The main storyline of "Boruto: Naruto Next Generations" follows the adventures of Boruto Uzumaki, the son of Naruto Uzumaki, as he navigates the challenges of being a ninja in a modern world filled with advanced technology and new threats. Boruto aims to create his own ninja way while also dealing with the legacy of his famous father and the responsibilities that come with it. The series explores themes of friendship, family, and the importance of finding one's own path in life.