Tarantulas are generally not considered dangerous to humans. While they do have venom to immobilize their prey, their bites are rarely harmful to humans and are often compared to that of a bee sting. However, some people may be allergic to tarantula venom, and in those cases, a bite could cause a more severe reaction. It's also important to note that handling tarantulas can be stressful for the spiders, which may lead to defensive behaviors such as biting.