In "Tokyo Revengers," the characters cope with feelings of regret and guilt in various ways. Some characters like Takemichi deal with their emotions by taking action and trying to make amends for their past mistakes. Others like Mikey try to bury their guilt by focusing on the present and moving forward. Additionally, characters like Draken find solace in their friendships and support systems, helping them navigate their feelings of regret and guilt. Overall, the characters in "Tokyo Revengers" demonstrate different coping mechanisms when faced with these complex emotions.