In Tokyo Revengers, the characters confront issues of trust and betrayal through their actions and relationships. The protagonist, Takemichi, often struggles with trusting others due to past betrayals and constantly questions the loyalty of those around him. The series showcases various instances where characters are put to the test and must decide whether to trust or betray one another, highlighting the complexities of human relationships and the consequences of such actions. Ultimately, the characters in Tokyo Revengers navigate these themes by learning to communicate effectively, rely on each other, and ultimately strive to build trust despite the challenges they face.