In "Tokyo Revengers," the characters navigate issues of trust and betrayal through complex relationships and moral dilemmas. The protagonist, Takemichi, struggles with figuring out who to trust as he deals with friends who may betray him or enemies who may surprise him. The characters often have to navigate between their personal loyalties and conflicting interests, leading to moments of both betrayal and redemption. Ultimately, trust is tested and bonds are formed and broken throughout the series, showcasing the intricate dynamics of human relationships in the face of adversity.