In Tokyo Revengers, the characters navigate issues of trust and betrayal through complex relationships and shifting alliances. The characters often struggle with knowing who to trust, as loyalties are constantly tested and betrayals are frequent. Some characters choose to trust their instincts and remain loyal to their friends, while others may be tempted to betray their comrades for personal gain or survival. Ultimately, the characters must navigate these challenges by learning from past betrayals, communicating openly with each other, and making difficult decisions based on their own values and beliefs.