The Mona Lisa's status as an icon has influenced its interpretation in various cultural contexts by making it a symbol of beauty, mystery, and sophistication. In different cultures, the painting's enigmatic smile has been seen as a representation of different emotions and ideas, ranging from contentment to deceit. Additionally, the Mona Lisa's fame has led to it being referenced in literature, music, and popular culture worldwide, shaping how it is perceived and understood across different societies.