The Mona Lisa's fame played a significant role in its theft in 1911 because its global renown and popularity made it a valuable target for art theft. The painting's iconic status led to it being seen as a symbol of prestige and power, making it a prime target for criminals looking to make a name for themselves or seeking to hold it for ransom or fame. Additionally, the widespread recognition of the Mona Lisa meant that it would be highly sought after on the black market by collectors willing to pay a high price for such a well-known masterpiece.