The significance of the Mona Lisa's gaze and eye contact with the viewer is that it creates an engaging and intimate connection between the viewer and the painting. The enigmatic smile and direct gaze of the Mona Lisa have intrigued viewers and art enthusiasts for centuries, leading to numerous interpretations and analyses. Some believe that her gaze symbolizes mystery and depth, while others see it as a reflection of her elusive and captivating personality. Overall, the eye contact in the painting draws the viewer in and invites them to explore the enigma of the Mona Lisa_