The Mona Lisa, painted by Leonardo da Vinci, has had a significant influence on the portrayal of women in art. The painting is admired for its serene and enigmatic expression, which has become a standard for representing femininity in art. The Mona Lisa's subtle smile and direct gaze have been emulated in various artworks throughout history, shaping the way women are depicted as symbols of beauty, mystery, and wisdom in the art world. The painting's fame and cultural impact have made it a timeless reference point for artists seeking to capture the essence of female beauty and allure in their own work.