Light Yagami's sense of superiority greatly affects his interactions with others as it leads him to believe that he is more intelligent and morally superior than those around him. This arrogance causes him to have a condescending attitude towards others, leading to manipulation, deceit, and a lack of empathy in his interactions. Ultimately, his sense of superiority blinds him to the consequences of his actions and leads to his downfall in the series "Death Note."