The interactions between Light Yagami and Near and Mello in the anime "Death Note" are significant as they represent the clash between two different approaches to justice and morality. Light, who initially posed as the self-proclaimed god of the new world using the Death Note to rid the world of criminals, is confronted by Near and Mello, successors to L, who challenge Light's actions and attempt to bring him to justice. Near represents a more strategic and analytical approach, while Mello is more impulsive and emotional. Their interactions with Light highlight the complexity of morality, power, and the consequences of playing god. Ultimately, the clash between Light and Near and Mello leads to a dramatic and intense conclusion in the series.