Light Yagami's interactions with other key players in the Death Note saga are significant as they showcase his complex relationships, manipulation skills, and strategic thinking. His interactions with characters like L, Ryuk, Misa Amane, and Near highlight his psychological warfare tactics, his ability to outwit others, and the moral dilemmas he faces as he seeks to reshape the world according to his vision. These interactions serve to deepen the plot, provide character development, and add suspense to the story as Light navigates the challenges presented by his adversaries.