Male and female guinea pigs may exhibit some differences in their personalities. Generally, male guinea pigs, also known as boars, tend to be more dominant and territorial compared to females, known as sows. Boars may be more vocal and assertive, while sows are often more social and nurturing. However, it's important to note that individual personalities can vary, and proper socialization and handling can help both male and female guinea pigs develop friendly and affectionate behaviors.