Domestic rabbits are bred to be docile and comfortable around humans, while wild rabbits are typically more skittish and cautious in their behavior. Domestic rabbits also tend to have a wider range of colors and patterns due to selective breeding, whereas wild rabbits are usually a uniform color to blend in with their natural environment. Additionally, domestic rabbits may have different dietary needs and living conditions compared to wild rabbits, as they are accustomed to being cared for by humans.