Cats communicate with humans in various ways, including vocalizations such as meowing, purring, hissing, and growling. They also use body language, such as rubbing against you, kneading, tail twitching, and blinking slowly to show affection or trust. Additionally, cats may use visual cues like ear position, eye contact, and facial expressions to convey their feelings and needs to their human companions. Understanding these signals can help strengthen the bond between cats and their owners.