Yes, guinea pigs can be litter trained, similar to how you would litter train a cat. It may take some time and patience, but with consistent training, many guinea pigs can learn to use a designated litter box. It's important to provide a large enough litter box filled with appropriate bedding material and to place it in a spot where your guinea pig tends to go to the bathroom. Regular cleaning and positive reinforcement can help encourage your guinea pig to use the litter box consistently.