The Thunder Breathing technique in Demon Slayer is significant because it is one of the five main Breathing Styles used by Demon Slayers to enhance their combat abilities and powers. Thunder Breathing focuses on enhancing physical strength and agility, enabling the user to deliver powerful and swift attacks to defeat demons effectively. The Thunder Breathing technique also plays a pivotal role in the character development of certain Demon Slayer Corps members like Zenitsu Agatsuma, who is known for his exceptional mastery of this technique despite his initial lack of confidence.