Yes, you can train a pet rabbit to use a litter box. Rabbits are naturally clean animals and can be easily trained to use a litter box filled with rabbit-safe litter such as paper-based pellets or hay. Place the litter box in a corner of the rabbit's living area where they tend to go to the bathroom, and encourage them to use it by placing some of their droppings in the box. With patience and consistency, most rabbits can be successfully litter trained.