In the Naruto anime series, some of the main characters include Naruto Uzumaki, Sasuke Uchiha, Sakura Haruno, Kakashi Hatake, and many more supporting characters like Jiraiya, Tsunade, and Gaara. The series also features various villains such as Orochimaru, Kabuto Yakushi, and Akatsuki members like Itachi Uchiha and Pain.