Mathematical principles play a crucial role in the design and analysis of computer algorithms. Through mathematical techniques such as calculus, linear algebra, probability theory, and discrete mathematics, computer scientists can analyze the efficiency and correctness of algorithms. These principles help in evaluating the running time of algorithms, determining the best data structures to use, and optimizing the overall performance of computer programs. Additionally, mathematical concepts are fundamental in understanding the complexity theory, which deals with classifying problems based on their inherent difficulty and the resources required to solve them.