Multi-signature wallets in Bitcoin are designed to enhance security by requiring multiple private keys to authorize a transaction. This means that in order to send Bitcoin from a multi-signature wallet, multiple individuals or entities must provide their respective private keys to validate the transaction. This reduces the risk of a single point of failure, as all parties involved must cooperate to access and move the funds. As a result, multi-signature wallets are considered more secure than single-signature wallets, as they add an extra layer of protection against unauthorized access or theft.